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These data were consistent with observations made using Affymetrix micorarrays (table 3) and correlated with the different degrees of induction of both IGF2 and H19 transcripts as quantified by real time PCR, ranging from 60 80 fold (batch 1and 2) to 600 700 fold (batch 4).
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The ASO tests showed an unexpected observation of a significant degree of induction of TLR-related genes by one of ASOs designed for the knockdown of the Gαi2 gene.
A similar correlation in the degree of induction of HMGCR and LDLR alternative splicing was seen after sterol loading in 31 lymphoblast cell lines incubated with 1 µg/ml 25-hydroxycholesterol.
The only difference was that the degree of induction of each gene was 1.25 (DHH) to more than 10 (IGFBP3) times greater in cells expressing the AML-associated fusion (Table 3).
Most AZT-induced gene expression changes occurred by 24 hours as indicated by the close relationship of AZT 24 to AZT 48, although the degree of induction of some up-regulated genes appears to be greater as exposure time is increased (more intense red in AZT 48 hr as compared to AZT 24 hr).
Interestingly, SCD1 expression was variably induced in Scd2-/ mice, and the degree of induction of SCD1 appeared to determine the chance of survival of Scd2-/ mice into adulthood.
Analysis by Cell-IQ Analyzer revealed a higher degree of induction of necrosis by thin CNTs and an increased proliferation rate upon incubation with thick CNTs.
GmIPT09 and GmIPT13 were significantly induced by drought in the V6-stage leaves; the degree of induction of these genes was higher in the younger trifoliate leaves [ 16].
Global expression data have suggested that the timing and the degree of induction of the defense pathway are determinants for the induction of soybean resistance to P. pachyrhizi [ 17, 20, 22, 60].
The degree of induction of the system at the level of the individual cell, as opposed to the population as a whole, is therefore likely to be much higher than reported.
Although the degree of induction of INPP4B by individual drugs differed, anti-apoptotic effects of INPP4B were clearly evident in all drug-treated cells, as demonstrated by morphological changes (Fig. 5B).
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