Whereas this suggests some degree of functional and evolutionary separation between catalytic activity (and regulation thereof) and peptide specificity, a separation of functions that is similar to those employed in other signaling systems (Goldman et al., 2014), our results also indicate that the activation segment provides a link between these biological functions.
This group difference remained significant after accounting for level of amputation and degree of functional and cosmetic prosthetic limb usage as covariates (F 1,24) = 8.217, p=0.009).
A similar correlation was also obtained after accounting for level of amputation and degree of functional and cosmetic prostheses usage (r(15) = −0.451, p=0.034).
Despite the apparent different origins of the archaeo-prokaryotic and eukaryotic NHEJ polymerases, these two end-joining systems share an unexpected degree of functional and structural commonality.
Our current data confirm that the cerebellum processes both vestibular-ocular and perceptual signals but with a degree of functional and neuroanatomical separation.
This study demonstrates, at the genomic level, that this elevated gene duplicability is associated with higher degree of functional and sequence diversification.
Homologous KIX domains have been identified and characterized in p300 as well as in human and yeast Mediator coactivator subunits, and their structures were determined recently, revealing a high degree of functional and structural similarity.
Due to the high degree of functional and sequence homology between AldO and HotAldO, we wondered if it would be possible to engineer HotAldO's thermostability into its less stable counterpart, AldO.
Compared to other vertebrate NR subfamilies, the evolutionary history of the NR1I subfamily is difficult to reconstruct due to a high degree of functional and sequence divergence [ 10, 12, 22].
The difference between the two 1-handed groups was also significant when accounting for level of amputation, and degree of functional and cosmetic prosthetic limb usage (F 1,15) = 11.357, p=0.004 and F 1,23) = 8.172, p=0.009 for residual arm and intact hand movements, respectively).
