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Our study's main limitation was documenting the degree of ventilation monitoring for non-specialized ground IFT.
A lung clearance index (LCI) has been another parameter also used to quantify the degree of ventilation heterogeneity.
Moreover, concordant with previous findings using MBNW, the degree of ventilation heterogeneity at baseline was also found to be correlated to AHR (Fig. 5) [32].
Moreover, we cannot quantify ventilation distributions from mechanical heterogeneity alone and whether the degree of ventilation degradation can lead to amplified mismatches in perfusion and eventually the ability to maintain proper blood gases.
Additionally, the degree of ventilation heterogeneity was also found to be correlated with measurements of lung mechanics [32], further reinforcing the relationship with asthma severity found from prior qualitative studies which compared measurements to spirometry [28].
Applying indices of S acin and S cond, the degree of ventilation heterogeneity at baseline has been found to be linked to the degree of AHR, a hallmark feature of asthma, and can also be used as a predictor of asthma control [71, 73 76].
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The reduced PvO2 further reduces PaO2 for the same degree of ventilation-perfusion mismatch [ 33].
In BOS patients, intrapulmonary pO2 had a wider distribution, indicating a greater degree of ventilation-perfusion inhomogeneity (Fig. 2).
The effect of protective ventilation strategies on mortality seems to be related to the decrease in cytokine response induced by mechanical ventilation, minimizing the degree of ventilation-induced lung injury and subsequent biotrauma [ 22].
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinical syndromes that are defined by varying degrees of ventilation perfusion mismatch, acute hypoxemic respiratory failure, bilateral pulmonary infiltrates (oedema and normal cardiac filling pressure), and poor lung compliance [ 1, 2].
Thus, respiratory charges are more likely a reflection of duration of mechanical ventilation rather than the degree of ventilator support necessary.
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