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The high degree of sequence variations of amino acid deletion or insertion of the ZA and BC loops indicates that different sets of residues in these regions of a BRD dictate its ligand binding specificity by interacting with residues flanking the Kac in a target protein [6].
Interestingly, in our distinct gene sets from each of three wild species, 70% of the transcription factors belonged to the AP2/ERF family, which suggest that in Chinese wild Vitis the distinct AP2/ERF genes might co-evolve with R genes and have a high degree of sequence variations.
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This degree of sequence variation between humans and chimpanzees is only about 10-fold greater than that seen between two unrelated humans.
This is also suggested by the large degree of sequence variation amongst OR genes in humans.
As occurs with many other RNA viruses, HCV exhibits a considerable degree of sequence variation over the whole genome.
They display a high degree of sequence variation in the cap gene regions encoding exposed loops and the receptor binding domain [10].
However they are mostly found in sequence regions that have a high degree of sequence variation and that have been identified as probable surface loops that are likely to form extruded unfolded domains.
While histone lysine acetylation plays a crucial role in regulation of chromatin-mediated gene transcription, a high degree of sequence variation of the acetyl-lysine binding site in the bromodomains has limited our understanding of histone binding selectivity of the bromodomain family.
Sequencing of several gene loci reveals high degree of sequence variation, but the biological significance of this finding is unclear.
Due to the high degree of sequence variation within most endemic areas, MSP1a sequences have failed to provide phylogeographic information on a global scale [ 7].
Protein-coding genes exhibit a higher degree of sequence variation and thus can be targeted as tools for differentiating strains of the same species.
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