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This degree of sequence variation between humans and chimpanzees is only about 10-fold greater than that seen between two unrelated humans.
This is also suggested by the large degree of sequence variation amongst OR genes in humans.
As occurs with many other RNA viruses, HCV exhibits a considerable degree of sequence variation over the whole genome.
They display a high degree of sequence variation in the cap gene regions encoding exposed loops and the receptor binding domain [10].
However they are mostly found in sequence regions that have a high degree of sequence variation and that have been identified as probable surface loops that are likely to form extruded unfolded domains.
While histone lysine acetylation plays a crucial role in regulation of chromatin-mediated gene transcription, a high degree of sequence variation of the acetyl-lysine binding site in the bromodomains has limited our understanding of histone binding selectivity of the bromodomain family.
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The high degree of sequence variations of amino acid deletion or insertion of the ZA and BC loops indicates that different sets of residues in these regions of a BRD dictate its ligand binding specificity by interacting with residues flanking the Kac in a target protein [6].
Interestingly, in our distinct gene sets from each of three wild species, 70% of the transcription factors belonged to the AP2/ERF family, which suggest that in Chinese wild Vitis the distinct AP2/ERF genes might co-evolve with R genes and have a high degree of sequence variations.
Degrees of sequence variation at the amino acid level, as well as phylogenetic relationships across different clades, were investigated.
In recent years, with the proliferation of DNA sequence data, it has become possible to consider the degree of evolutionary conservation when predicting the phenotypic consequences of sequence variation.
Also of interest is the high degree of tir sequence variation relative to that found in eae, even though the two proteins encoded by these genes interact together as receptor and ligand during adherence to host intestinal epithelial cells.
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