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As expected, if no special selective effect resulted from being associated with leeches as a vector, the degree of sequence change is equivalent to that found when the 16S rRNA gene sequence of the Chiloé Island sample is compared with other members of Rickettsia not associated with leeches (sequence similarity 91.6%).
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Such as, PTEN gene and the PTEN pseudogenes (ptenp1, one of lncRNAs) share a high degree of sequence homology, changes in ptenp1 expression levels indirectly affect PTEN expression by sequestering PTEN-targeting miRNAs.
If their function is as important as the extreme degree of sequence conservation would indicate, inconsistent regulation of target genes might cause dramatic change in vertebrate development with potentially profound effects.
Comparison of the amino acid sequences of GRKs from various mammalian species indicates that GRK2, GRK5, and GRK6 exhibit a remarkably high degree of sequence conservation, whereas GRK1 and particularly GRK4 have accumulated amino acid changes at extremely rapid rates over the past 100 million years.
There was a relatively low degree of sequence variation between the M. spretus strains; however we identified twenty-two changes that resulted in intra- spretus amino acid polymorphisms.
Remarkably, there are only a few changes in which enzymes retain a relatively high degree of sequence and functional similarity.
This functional difference has been hard to understand given their high degree of sequence homology.
They show a high degree of sequence and structural conservation.
The high degree of sequence conservation suggests there are regulatory sequences located in the Ring1B 5' UTR.
The degree of sequence identity varied substantially.
Accuracy of prediction depends on the degree of sequence similarity.
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