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Although using vascular wall uptake in the femoral artery as reference has a theoretical drawback of a lower sensitivity (when the femoral artery is involved in the disease process, as observed in our study), its specificity and degree of observer agreement render it a good alternative when liver uptake is unclear (e.g., in patients with liver diseases causing nondiffuse liver uptake).
Multivariate statistical analyses revealed segregation of the approaches according to the landscape concept applied, the degree of observer independence and various other factors involved in the landscape characterisation process.
Additionally, clinical assessment has a high degree of observer variability.
A certain degree of observer variability is unavoidable (because of among others' cognitive and memory effects).
However, problems arise when comparing the degree of observer agreement among different methods, populations or circumstances.
However, problems arise when comparing the degree of observer disagreement between two different methods, populations or circumstances.
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Immunostained TMAs were examined independently by two pathologists and a high degree of inter-observer concordance was achieved (r>0.7, p<0.0001) as well as intra-observer concordance on different sessions (r = 0.79, p<0.0001).
Although there was just one observer in this study, which may be considered as a potential limitation, there was a high degree of intra-observer agreement.
A high degree of inter-observer agreement was seen on a Bland Altman test with a maximum observed difference of 10%.
In addition, the observed trend that the correlation between CEIP and HEIP corresponded to the degree of inter-observer agreement requires further investigation.
. To evaluate the degree of inter-observer concordance in the blood pressure figures taken by a nurse and a doctor with a mercury sphygmomanometer and by the patient with a semi-automatic device.
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