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To further explore this hypothesis, we examined the degree of linkage between both loci.
These results indicate a certain degree of linkage between HER2 and Erk5 overexpression.
At a similarity threshold of >75%, the clustering coefficient c (degree of linkage between nodes) of 5' half was only 0.17 while 3' half was 0.47, which means that 47% of all possible connection are used.
TERT expression profiles for rs7736074 and rs4975596 were nearly identical, reflecting the high degree of linkage between these polymorphisms.
The ability of DArT-BSA to quantify the degree of linkage between markers and a target locus is a clear advantage in such cases.
The degree of linkage between markers was reflected by 'Gap < = 5' ranging between 78.57% and 98.85% with an average value of 91.76%.
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One interesting cause of heterogeneity occurs when the "heterogeneous" variant is merely a tag for the truly functional variant (or multiple rare variants each with strong functional effects) and the degree of linkage disequilibrium between these variants differs between series leading to weaker and/or opposing effects.
Complicating assessment of TNF-α polymorphisms is the high degree of linkage disequilibrium between TNF-α promoter polymorphisms and between other polymorphisms within other nearby genes, many of which also have significant inflammatory roles.
In the JS series, HaploView [46] was employed to determine the degree of linkage disequilibrium between the variants identified through our de novo search that could be genotyped with TaqMan assays.
There was a high degree of linkage disequilibrium between Pro12Ala and C-2821T.
We examined the degree of linkage disequilibrium between these XPD polymorphisms among controls and found Asp312Asn and Lys751Gln did co-segregate (D′ = 0.68).
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