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Thorough examination of well-conserved residues in these structures, by point mutation and functional assay with the Xenopus oocyte recording system, strongly suggest that these "loops" include three β-turns and some degree of folding.
Their general ease of expression and refolding and straightforward methods to monitor their degree of folding conspire to make OMPs excellent model systems to investigate how the membrane environment and other biological factors modulating the membrane insertion and folding of OMPs influence the folding pathway.
For both groups, an increase in the degree of intrinsic curvature (decreasing curvature skew) was correlated with an increase in the degree of folding.
Note that unlike the macroscopic persistence length, the microscopic persistence length does not correspond to the stiffness of a polypeptide chain but represents the degree of its folding; a shorter microscopic persistence length reflects a higher degree of folding.
In five out of six cases, the degree of folding is immature, while in the sixth case (case 3), a mature folding pattern of the nucleus can be gauged by observing the outline of the astroglial scar.
The fishes that swim faster thus tend to have a greater degree of folding and overlapping.
Similar(33)
The degree of leaf folding in L. rigidus again followed a 'U-shaped' pattern with folding highest in the sheltered forest zone then declining gradually and rising in the open savanna proper (P < 0.001; Fig. 6B).
The colour scale indicates the degree of fold change expression values (light blue-blue, down-regulation; pink-red, up-regulation).
In addition, according to our results, the degree of maturation of the gland is related to essential oil synthesis and cuticular cavities filled by these oils, leading to an important increase in gland diameter, regardless of the degree of fold, and also this aspect is linked to the water and nutritional status of plants.
The average degree of correlation in PCMs and PCAINs were also computed for each family, providing a quantitative estimate of the degree of fold-conservation for these scores (diagonal entries from top left to bottom right; Figure S5).
The influence of the degree of fold change on data correlation will be discussed later.
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