Sentence examples for degree of esc from inspiring English sources

It has been recognized that aggressive and poor prognostic glioblastomas, as well as other tumors, acquire characters reminiscent of embryonic stem cells (ESCs) and the degree of ESC gene expression correlates with patient prognosis [ 36].

In poorly differentiated breast cancer, gliomas and bladder carcinoma, an embryonic stem cell (ESC -like gESC -likession sigeneurexpressionited and the degree of Esignaturem recapisulation correxhibitedth tumor stands and pathent survival [ 13].

The levels of the ESC-specific cell-surface marker SSEA-1 have been shown to inversely correlate with the degree of ESC differentiation.

The key protein, Activin A, plays a positive role in generating chimeras with a higher degree of ESC contribution via impeding the EPI lineage development of host embryos.

We determined the degree of ESC incorporation in the WT/mdx skeletal muscles by quantitating the percentage of DNA containing the LacZ transgene.

This suggests that although depletion of Cbx7 results in a degree of spontaneous differentiation, ESCs that have low levels of Cbx7 can still self-renew.

Mouse secondary iPSCs generated in our lab are an extraordinary model to inspect the degree of difference between iPSCs and ESCs because secondary iPSCs meet the ESC gold-standard for the full-term development of germ-line transmittable all-iPSC mice.

We identified 221 genes that were expressed at least 3-fold more greatly in Zfp42-GFPd2-high ESCs than in Zfp42-GFPd2-low ESCs and that also show a significant degree of misregulation in Mbd3 −/− ESCs (Table S1).

Representative images of FIB (Fig. 4D,E), IPSC (Fig. 4F,G), TER (Fig. 4H,I) and ESC lines (Fig. 4J,K) showed an apparent high degree of similarity among FIB, IPS, and ESC mitochondria, and a distinct difference in the morphology of TER mitochondria.

We further characterized the function of miRNAs differentially expressed under two conditions and found that ESCs exhibited higher degree of dependency on miRNAs for rapid proliferation; since Dgcr8−/− or Dicer1−/− but not wild-type ESCs showed slower growth rate and more accumulation in the G1 phase under 2i than serum condition.

Critically, a high degree of similarity exists between iPSCs and ESCs, offering new hope for the use of pluripotent stem cells for regenerative therapies with fewer ethical concerns and, potentially, enhanced patient specificity.