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Figure 2 shows the X-ray dose modification results against the predicted degree of dose enhancement, based on the gold concentrations and X-ray energies used for a range of experimental studies (Butterworth et al. 2012).
The treatment for B ALL patients centres on the use of classical cytotoxic chemotherapy drugs used with a high degree of dose intensity.
In the United States, the Food and Drug Administration advised that irinotecan dosing should be reduced for individuals homozygous for UGT1A1*28 allele (United States Food and Drug Administration, 2005) but do not specify the degree of dose reduction.
Age-appropriate oral formulations are expected to meet all the quality attributes of conventional pharmaceutical products as well as specific patient requirements (e.g., higher degree of dose flexibility and ease of swallowing).
Therefore, if the region of high FDG accumulation is near the OARs, it might be necessary to reduce the degree of dose escalation and/or reduce the volume to increase irradiation dose (e.g., lesion with SUV > 2.5).
Compared to traditional IMRT or 3-dimensional conformal radiotherapy (3DCRT), a higher degree of dose conformity and homogeneity in the target can be achieved for HT due to larger number of degrees of freedom in beam arrangement during gantry rotations to fit the lesion slice by slice, while sparing the adjacent OARs at the same time [ 8– 13].
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By contrast, the response to AC220 varied considerably, displaying flat curves in general, with a degree of dose-dependant response before reaching a plateau, sometimes with a cell survival of >50%, despite the full efficacy obtained in MV4-11.
Here, we determine the degree of warfarin dose reduction associated with kidney impairment and make recommendations for warfarin dosing.
How the radiation accumulates depends on the degree of exposure — dose and duration — and the half-life of the element, said Hei. Depending on its chemical form and by what organisms it is taken up, radiation can also concentrate when it moves through the food chain.
CK plans had the greatest degree of target dose inhomogeneity.
Potentially, one could manipulate the degree of exposure (dose) by manipulating the stringency of the intervention.
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extent of dose
degree of exposure
degree of radiation
degree of agent
degree of administration
errors of dose
ranges of dose
degree of perfection
degree of fineness
degree of difficulty
degree of pragmatism
degree of receptivity
degree of effectiveness
degree of supervision
degree of sportsmanship
degree of impunity
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