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Exact(9)
(ii) Burial of polar groups in the non-polar interior of a protein is highly destabilizing, and the degree of destabilization depends on the relative polarity of this group.
The degree of destabilization of PNIPAM progressively increases with increasing concentration of the denaturant.
The risk of ccRCC in VHL disease is linked to the degree of destabilization resulting from missense mutations.
We see a sigmoidal curve that may indicate a certain degree of destabilization is necessary in order to achieve rapid release.
We then demonstrate that the degree of destabilization is such that the native state is only about 7.3-fold (1.16 kcal/mol) more stable than a kinetic intermediate.
In contrast, we report a clear difference between ccRCC- and non-ccRCC-associated missense mutations; the risk of ccRCC in VHL disease is significantly associated with the degree of destabilization resulting from the mutations.
Similar(50)
Different coagulants affect different degrees of destabilization.
However, there is not a strict quantitative criterion for the degree of membrane destabilization expected for a fusion peptide.
Although the destabilization of the DGC may contribute to the muscle cell necrosis in adbn−/− mice, it appears that the degree of dystrophin destabilization is insufficient to render the membrane susceptible to damage, cause costamere disorganization or alter the functional performance of the skeletal muscle.
The magnitude of oxidative stress determines the degree of lysosomal destabilization and, consequently, whether arrested growth, reparative autophagy, apoptosis, or necrosis will follow.
Destabilization of post-session ratings was highly synchronous and the level of destabilization corresponded highly in successful therapies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com