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By the degree of cell differentiation HCC are divided on high-differentiated, moderately differentiated, low- and undifferentiated types.
Furthermore, regulating the degree of cell differentiation in vitro is desirable for a more effective regenerative therapy.
The expression and activity of this enzyme seems to correlate with the degree of cell differentiation.
The pattern of cytokeratin expression is a marker for the degree of cell differentiation and transformation [6].
It should be outlined that some differences observed in Tβ4 immunoreactivity between fetuses and adult organs may be related to the different degree of cell differentiation.
IGFBP5 expression is associated with the degree of cell differentiation in different cancers [84], [85].
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In addition, expression of a dominant active form of EGFR, λTop [71], in sav follicle-cell clones located at a non-posterior region in the egg chamber did not exhibit the degree of cell-differentiation defect that was shown in sav PFC clones alone.
13 In this study, PD-L1 expression was significantly correlated with degree of tumor cell differentiation and stage of tumor node metastasis.
The degree of cancer cell differentiation may explain some of these differences.
The degree of fat cell differentiation can also be measured by the expression level of lipid synthesis proteins or their controlling transcription factors (Fig. 2B) [3].
Herein, we report that GADD34 expression is correlated with the degree of mesothelial cell differentiation, whereas CHOP expression is an independent predictor of prognosis in malignant mesothelioma.
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