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Even though fluoroscopy has not yet been applied to the elbow, this joint is of particular interest for its validation because it is characterized by (i) a high degree of bone superimposition, (ii) being composed by thin long bones (in contrast with the typical morphology of knee prosthesis), and (iii) marked longitudinal cylindrical symmetries (especially for the radius).
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Moreover, the availability for harvesting intraoral bone blocks is limited [13, 14] and these autologous bone grafts may suffer a high degree of bone resorption during healing [15].
The degree of bone mineralization is a fundamental determinant of bone quality and correlates with bone stability [ 4, 5].
A good relationship was shown between the degree of superimposition and the inhibitory activity, except in one case, implying that candidate haptens can be computationally selected.
The in vivo in silico simulation using physiologically based pharmacokinetics (PBPK) model and population simulation (100 subjects) revealed a reasonable degree of superimposition of simulated and observed pharmacokinetic parameters based on overall fold error (≤2.0).
While in panel A the blue and the red peaks clearly alternate, in panel B the trend is less clear, showing some degree of superimposition of the two traces during some of the trials.
This analysis revealed a strong but comparable degree of superimposition of the origins of projections directed to CAC and PMd, CAC and PMv, RAC and PMd, and RAC and PMv, ranging from 14%to20%0%.
After Procrustes superimposition, the aligned coordinates present more dimensions than the actual shape space (aside from the degrees of freedom lost in superimposition, a maximum of 48 dimensions is needed to describe 49 species means).
Difficulties of CR for a detail evaluation of wrist joints are mainly due to a projectional superimposition of bones in this complicated anatomical area, high irregularities of the bone margins (e.g. at level of ligaments attachment) and the presence of nutritive foramina that can appear like erosions.
Properties related to bone strength include rate of bone turnover, bone mineral density, geometry, microarchitecture, and mean degree of mineralization.
A novel analysis technique (SuperImposition by Translation And Rotation) is used to create mean curves of bone maturity score by gender and ethnicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com