However, when misfolded protein aggregates are not degraded efficiently by proteasome machinery, their efficient disposal is essential for cell survival, because misfolded protein aggregates are toxic.
On one hand, the raw materials without pretreatment could not be degraded efficiently by fermentative bacteria, which led to the low methanogenesis efficiency [ 16, 30].
For successful mitosis, Cyclin B1 and Securin must be degraded efficiently before anaphase.
Likewise, Sf9 cells expressing a mutant haem-deficient enzyme accumulate high levels of cGMP, which cannot be degraded efficiently by endogenous PDEs42.
Ex situ oxidative treatment, with diluted oxygen, revealed to degrade efficiently adsorbed compounds, thus leading to a total recovery of activity.
It grows at pH 6.85, 30 °C, and inoculum concentration 1.45 g/L and degrade efficiently 90 5 PCNB in 7 days.
Apparently, the microorganisms in the floating layer were not able to degrade efficiently the accumulated organic acids, although Syntrophomonas-like organisms which are known to withstand high VFA concentrations were detected in the floating layer [44].
First, although human ERAP1 degrades efficiently relatively long peptides (9 15 residues long) its activity seems to dramatically decrease for peptides 8 residues and smaller [15], [16].
However, recent data demonstrates that polyglutamine tracts are degraded efficiently by eukaryotic proteasomes, thereby refuting the proposal that mutant polyglutamines block 26S proteasome function by becoming trapped inside the 26S proteasome [18].
Because full-length CFTR ΔF508 is degraded efficiently by the proteasome and because deletion of F508 altered NBD1 conformation directly, we anticipated that this conformational change would affect biological stability of the NBD1 domain in intact cells.
