IκB-α was rapidly degraded upon stimulation with TNF-α, and plumericin (5 μM) completely inhibited this degradation process.
Proteomic analysis revealed that SMAD4 interacts with SKI, a transcriptional repressor that is degraded upon TGFβ stimulation.
PIE-1 is degraded upon the birth of the germ cell precursors, Z2 and Z3.
It degraded upon incubation in phosphate-buffered saline (PBS) at 37 °C and sustained the release of bioactive plasmid DNA up to 2 months.
Importantly, substrates bearing these tags are stable in the absence of SspB in vivo but are rapidly degraded upon SspB induction.
DAXX recruits Rassf1C into PML nuclear bodies and releases it when DAXX is degraded upon DNA damage (Kitagawa et al., 2006).
Detailed evaluations indicate, however, that glyphosate residues released from plant roots cannot be assumed to be entirely or permanently immobilised, or degraded, upon contact with soil.
On the other hand, ADP was strongly affected by acidic condition as preliminary studies showed that almost all the drug was degraded upon boiling with 1 M HCL for only 10 min.
It may therefore be suggested that this ubiquitous material, commonly deemed environmentally persistent [63, 140, 143, 144] and therefore paradoxical (since it does not accumulate in the environment) [145, 146], is also degraded upon exposure to sunlight.
However, in BEAS-2B bronchial epithelial cells, IκBα was not degraded upon similar treatment with FHA (Fig. 1C).
On the contrary, cereals and grains are poor sources of folates, which are further degraded upon storage and cooking [50].
