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(Although sperm have mitochondria, they typically degrade shortly after fertilization). .
(Sperm have mitochondria, but they are thought to degrade shortly after fertilization).
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Bound LPS molecules are degraded shortly, freeing up the receptor.
The detrimental effects of the use of sperm stained with these probes in ART are theoretically low, as it is well established that sperm mitochondria enter the oocyte upon fertilization but are degraded shortly thereafter [52].
The defective protein retains substantial chloride-channel function in cell-free lipid membranes, but when synthesized, the protein is rapidly recognized as misfolded and is degraded shortly after synthesis before it can reach its crucial site of action at the cell surface [67].
In some species, such as bovines [ 18], sperm mitochondria are ubiquitinated and thus degraded shortly after fertilization (figure 1 c).
Because ZFN proteins delivered directly into cells were degraded shortly after internalization, this approach led to fewer off-target effects than expressing ZFNs from plasmid DNA.
Oocyte-derived mRNAs are degraded shortly after fertilization, and ∼90% of RNAs stored in the oocyte are degraded by the 2-cell stage, which is an essential process for embryogenesis (Stitzel and Seydoux, 2007).
There are two hypotheses accounting for protein equilibrium in aneuploid cells: (i) the activity of the translational machinery may decrease or (ii) the excess proteins may be degraded shortly after being synthesized [ 15].
Consistent with this, it has been found that at most a few percent of polypeptides are degraded shortly after synthesis, suggesting that most are protected from proteolytic enzymes [ 59].
A construct ΔNDF-NES (132 449) of FMRP, which starts after NDF, degraded completely shortly after purification.
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