Sentence examples for degradation stabilisation from inspiring English sources

Heat-shock protein 90 (HSP90) is a molecular chaperone responsible for degradation, stabilisation and activation of a variety of proteins, including HER2, CRAF, BRAF, AKT and MET.

Besides the promoter and intronic sequences, elements in the 3′UTR play an important role in polyadenylation, nuclear export, degradation, stabilisation, and translation of the transcripts (Kuersten and Goodwin, 2003).

N-acetylglucosaminyltransferase V glycosylation of lamp-1 inhibits its degradation, and the stabilisation of lamp-1 results in increased extracellular matrix degradation (Fukuda, 1991; Kundra and Kornfeld, 1999).

These sequences are involved in the recruitment of ARE-binding proteins that contribute to mRNA stabilisation or degradation [ 18].

JAB1 and p53 bind competitively to the same domain of HIF-1 α resulting in either stabilisation or degradation of HIF-1 α respectively.

Thus, under euoxic conditions HIF-α is continuously expressed and rapidly degraded whereas under hypoxic conditions, prolyl hydroxylation and proteasomal degradation are slowed, resulting in stabilisation and accumulation of HIF-α.

While much research has been undertaken into understanding the degradation processes and development of stabilisation treatments for iron gall ink on paper [2, 8, 9] significantly less research has been undertaken on the iron-tannate dyed textiles that are the focus of this paper [3, 4, 10 13], and at present there is no suitable non-aqueous treatment with which to stabilise these objects.

Evidence suggests that phosphorylation of p53 at Ser20 leads to inhibition of the p53/MDM2 interaction, preventing ubiquitin-mediated p53 degradation and thereby enhancing p53 stabilisation [ 11- 13].

The paper presents newly obtained findings about the behaviour of brick masonry walls under static loads in their degradation phase in relation to their stabilisation and reinforcement with composites.

ARF binding enhances the degradation of Mdm2, resulting in p53 stabilisation [ 23, 25].

This suggests that although an increase in AR expression is associated with AR amplification, an increase in expression may also be due to alternative mechanisms, for example, decrease in protein degradation or an increase in protein stabilisation.