Sentence examples for degradation of specificity from inspiring English sources

Previous studies show that BA induces proteasome-dependent degradation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 in prostate cancer cells and this study focused on the mechanism of action of BA in colon cancer cells.

Betulinic acid had already been described to inhibit prostate cancer growth though a mechanism of action involving the decreased levels of VEGF and survivin due to the increased ubiquitin-mediated degradation of specificity protein transcription factors (Sp1, Sp3, and Sp4; Chintharlapalli et al. 2007).

As release of I− may result from non-specific degradation of substrate [30], the specificity of D2-like activity identified in osteoblastic cells [51] requires clarification.

Degradation of a dual-specificity phosphatase cell division cycle 25A (Cdc25A) involved in G2/S transition is also CRL dependent.

The degradation kinetics of ACTR is shown in Fig. 3. HPLC results of specificity part (forced degradation studies) of ACTR suggested the degradation behavior tabulated in Table 3. ACTR was observed to be degraded to about 40% under acidic conditions, when treated with 1 mol/L HCl for 6 h at room temperature.

It is worth noting that due to the 4qA-specific SNPs residing at the 3' end of the 4qA BS PCR oligonucleotide primers, multiple rounds of primer freeze-thaw, which leads to partial primer degradation, results in a loss of specificity and a consequent amplification of minor products from genomic DNAs lacking the 4qA allele (Additional file 1: Figure S1B).

Specificity of degradation of proteins is mediated in part by poly-ubiquitination of the substrate bound for destruction.

The stromelysins have relatively broad substrate specificity, catalyzing degradation of many different substrates in the ECM [ 1**, 2**].

E3 ubiquitin ligases play a key role in cellular functions by determining the specificity for degradation of substrates, marking it for degradation by the proteasome or the lysosome.

MMP-1 is a secreted enzyme and has wide substrate specificity for degradation of collagens, aggrecan, versican, serpins, and tenascin-C [ 33].

The HPLC monitoring of strictosidine disappearance confirmed the specificity of the CrSGD enzymatic reaction and excluded the possibility of non-specific degradation of strictosidine.