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Current MRI technologies are elucidating the substantial involvement of axonal degeneration with increasing disability parameters [ 5], previously difficult to define.
We now demonstrate a progressive reduction in corneal sensitivity and increasing corneal nerve degeneration with increasing severity of diabetic neuropathy.
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After nitrate administration, there was hepatocellular degeneration with increased intercellular space of the liver cells in groups B and C. Liver MDA, osmotic fragility and liver histology have returned to nearly normal in group D. These findings show clearly that high nitrate ingestion can cause pathological changes in liver histology and functions.
Despite their lack of involvement in synapse phagocytosis, microglia rapidly respond to the presence of synaptic degeneration with increased or de novo expression of different proteins and a change in morphology (Rao and Lund, 1993; Jensen et al., 1999).
Future work should now use the minimally invasive sampling technique to focus on the development and evaluation of strategies for detecting and reversing these pathological adaptations early in the progression of disease, in order to prevent further tissue degeneration associated with increasing tear size.
As the prevalence of the no degeneration and isolated anterior degeneration patterns decreased with increasing age group, the prevalence of the combined anterior/posterior degeneration pattern increased.
A graphical display of this information shows that as the prevalence of the no degeneration pattern and the isolated anterior degeneration pattern decreased with increasing age group, the prevalence of the combined anterior/posterior degeneration pattern increased.
Immunopositivity for CA12 was found to be high in the human immature NP, lower in the adult non-degenerate NP and higher with increasing degrees of degeneration, with its higher expression being proposed to correlate with the high metabolic developmental processes and as a response to injury.
The strength in the central regions of the superior endplates was reduced with increasing degeneration, but this was not observed peripherally (p=0.001).
For example, fibronectin content increases with increasing degeneration and it becomes more fragmented [ 38].
A compressive test on the nucleus demonstrated that the effective aggregate modulus decreases with increasing degeneration, whereas the permeability gradually increases [ 6].
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