Sentence examples for degeneration pathway from inspiring English sources
They also see strong potential in this work to represent a novel secretory vesicle degeneration pathway.
To investigate the N-APP-DR6-induced degeneration pathway at the molecular level, obtaining abundant and purified N-APP is fundamental and critical.
To conclude, these studies have now firmly established the order of two core events in an emerging WLDS-sensitive and SARM1-dependent axon degeneration pathway.
Our data show an increase in DNA methylation in dying photoreceptors in all four RP animal models analyzed, suggesting DNA hypermethylation as a common denominator in the photoreceptor degeneration pathway.
Those studies focused on RGC body death, although the axonal degeneration pathway in the optic nerve has not been well documented in spite of evidence that the mechanisms of degeneration of neuronal cell bodies and their axons differ.
Intriguingly, an NMNAT2 depletion-dependent accumulation of NMNAT substrate, NMN, also appears to be a critical pro-degenerative signal in both situations (this study; Di Stefano et al., 2014), strongly suggesting they are each mediated by activation of the same NMN- and SARM1-dependent degeneration pathway.
This strengthens the hypothesis that parallel degeneration pathways are involved in excitotoxin induced axon degeneration.
In this respect, caspase activation may act in parallel with other axon degeneration pathways involving NAD+ in this model [ 38].
Moreover, the optical transparency of zebrafish and the superficial location of peripheral sensory neurons present a novel method for identification and interrogation of compartment-specific degeneration pathways in aSyn toxicity.
Our characterization of the relationship between axonal fragmentation and cell death in this model does not rule out the possibility that independent, compartment-specific degeneration pathways are activated by aSyn.
The discovery that the chimaeric Wlds protein, which arose as a spontaneous mutation in a substrain of C57BL mice, leads to dramatic slowing of Wallerian degeneration (Mack et al., 2001), implies that in wild-type animals there must be biochemical processes to both activate and inhibit the axon and synapse degeneration pathways.
