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Typical degeneration features that were found included slower kinetics, oxidation and delamination upon cycling of the switchable mirror.
PGC-1α knock-out mice exhibit impaired mitochondrial functions, a hyperkinetic movement disorder and striatal degeneration, features also observed in HD patients (12, 13).
Marked differences in the prevalence of spinal degeneration features occur in association with older age, female sex, post menopausal women and obesity.
Linear regressions and partial correlation were used respectively to determine the association between each of disc degeneration features, BMD, and both CTX and osteocalcin.
Immunohistological analysis demonstrated full recovery of axonal degeneration features as measured by APP and synaptophysin staining, and decrease of activated astrocytes and microglia (Supplementary Fig 3 and Supplementary Table).
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We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tomography reflective drusen substructures (ODS) and examine their associations with age-related macular degeneration (AMD related features and AMD progression.
Syndromal deafness as well as retinal degeneration are features of the Usher syndrome in humans.
Our data suggests that excitotoxin induced axon degeneration shares features of both Wallerian degeneration and developmental axon pruning.
Mice lacking key genes of iron homeostasis – ceruloplasmin, hephaestin and hepcidin — developed retinal degeneration with features of AMD [ 45, 46].
Another success for pharmacological intervention has been achieved in the double-KO Abca4 −/−; Rdh8 −/− mouse, a model for rod and cone degeneration, resembling features of Stargardt disease.
The current study suggests that excitotoxin induced axon degeneration involves features of both Wallerian degeneration and growth factor withdrawal and that alteration in microtubule dynamics are an upstream event in axon degeneration.
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