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If cells are primed by the degenerating environment present in HD progression but do not have the appropriate signals to proliferate there will be no increase in neurogenesis.
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One possible explanation for the increase in neurosphere numbers observed in the 33-week-old HD hippocampus is that the degenerating hippocampal environment present during HD progression may in fact lead to the release of factors in vivo which may help to maintain the stem/progenitor cell pool at its normal adult level, but not allow these cells to actively proliferate.
Álvarez-Caudevilla et al. considered a cooperative reaction-diffusion system in a spatiotemporally degenerate environment [10].
Blackness, in the course of the eighteenth and nineteenth centuries, became seen as a mere disease, with negroes descended not from Adam or even the fabled "mark of Cain" but degenerated from corrupted environment, atavistic savagery, or worse.
However, the hostile environment of the injured or degenerating nervous system is known to be detrimental to the survival of NPCs and newborn neurons thereby limiting the capacity for regeneration and repair.
The cell-type-specific expression patterns of STAT proteins in human lymphocytic thyroiditis reflect their distinct and partially antagonistic roles in orchestrating the balance between degenerating and regenerating processes within a changing cytokine environment (Staab et al. 2012).
This finding is different from ball bam Δ86 double mutant GSCs that were not degenerating while they resided in the niche (supplementary material Fig. S3D), i.e. in an environment that promotes the undifferentiated state of GSCs.
The neuroprotective effects of activated microglia in inflammatory environments are partially overlapping its phagocytotic, destructive ones and may be triggered by signaling molecules produced by degenerating neurons, such as CX3C chemokine fractalkine (FKN).
Tent life is degenerating".
Darek's spinal cord was just degenerating".
Lately, though, that relationship has been degenerating.
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