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A randomized controlled trial might be necessary to definitively support the removal of TIVAP in case of severe sepsis or septic shock.
Current evidence does not definitively support or exclude a benefit of this magnitude, but ongoing randomized trials have sufficient statistical power to do so.
Although a study of this nature cannot definitively support or refute the hygiene hypothesis, it does provide a novel snapshot of disease prevalence in rural Andean villages of central Peru.
Our results also do not definitively support the postulate that focal imaging patterns may predict improved clinical outcomes by reflecting Y-90 localisation to areas of synovial disease activity [12, 13].
We found no evidence to definitively support any other potential RhoGEF as interacting with Rho1 during leg development, although we did identify two deficiencies that uncover putative RhoGEF genes that strongly enhance the malformed leg phenotype of Rho1E(br)246 (Table 4).
Future replications and mechanistic studies are required to definitively support the associations observed in this study.
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"Despite several attempts, we were unable to obtain results definitively supporting the major claims" of their publication.
A lower susceptibility to NHL among African HIV+ populations has also been hypothesized since in the USA, between 1981 and 1994, the proportion of NHL as an AIDS-defining illness was estimated lower in the black (1%) compared to the white population (3%) [98], although no specific genetic argument definitively supports this hypothesis.
However, the presented evidence falls short of definitively supporting this conclusion.
Slow accrual was a problem in our study, preventing it from either definitively supporting or refuting the results of the Nordic study.
Clinical results also have not definitively supported either preserving or removing the PCL, as studies have demonstrated similar clinical outcome scores for retention and excision of the PCL.
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CEO of Professional Science Editing for Scientists @ prosciediting.com