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Direct head-to-head trials and/or further appropriately powered clinical experiences (including long term safety data), along with robust pharmacoeconomic studies, are mandatory to more definitively position mavrilimumab relative to other currently available DMARDs.
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Peach (Prunus persica L. Batsch) was definitively positioned as a new fruit model when its genome was sequenced and released in 2010 by an international initiative [ 1, 2].
"I wish we had stood up Monday morning and said, definitively, the position of the Gore campaign is we would support the inclusion of any ballot with a postmark or a date," Mr. Klain said.
He said Cameron's draft bill, which is likely to be tabled by a backbencher as a private member's bill, would "entrench" the party's commitment to holding a vote in 2017 and force the other parties "to decide definitively their position".
In the presentation of the data it was not possible to determine definitively the position of the double bonds within given fatty acids by DI-ESI and so they are defined in terms of the number of carbons and degree of desaturation within the fatty acid, while presumed names are given in parentheses.
In the end, though, a failure to resolve definitively Greece's position in the single currency can only drain business spirits across the continent.
The pledges to put 'stability before tax cuts' and to 'love the NHS' were designed to inspire trust in the party, underlining that it had arrived at a definitively post-Thatcherite position.
Hoof It was third, in a desperate finish, but the stewards were not satisfied that Hoof It lost sufficient momentum for Dream Ahead to have definitively improved his position.
Although this did not yet definitively define the position of the city during the Reformation, it would be allied again with Zürich and Bern, and only after the defeat of the Schmalkaldic League in 1548 its close connections to the Eidgenossenschaft would be finally severed it was another factor contributing to the growing estrangement between the Swiss and the Swabians.
Over the past four years, during the term of the Socialist president, Michelle Bachelet, the Pinochet family was definitively dislodged from its position at the heart of Chile's political right wing, following the revelation that the General and his associates had controlled multiple secret U.S. bank accounts which contained millions of dollars, presumably ill-gotten.
Consequently, she will be able to construct her scientific theories without ever falling prey to worries about whether her work has value, and perhaps even more importantly she will be in a position to definitively put an end to theoretical disagreements with others.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com