But the scientists also said they could not "definitively exclude" the possibility that levels of viral markers in the blood might fluctuate over time and become undetectable at certain periods.
The reactivity of a monoclonal antibody in a western blot format does therefore not definitively exclude its reactivity with a structured epitope.
We cannot definitively exclude the concern that our data of decreased STAT5 phosphorylation and increased SOCS mRNA and protein levels may be confounded by the fact that the Gfi1+/+ and Gfi1−/− cell populations differ in various respects.
Yet, those studies cannot exclude a maternal effect or signalling through other receptors, and thus further in vivo investigations are warranted to definitively exclude such a role for BMP signalling in vivo.
Next, to definitively exclude the role of feeder cells in promoting FGF-iPS stem cell properties, we serially cultured FGF-iPSCs on fibronectin-coated plates in the absence of fibroblast feeder cells.
In that study we did not find an association between C677T MTHFR polymorphism per se and NVAF [9], but those results were not conclusive, because the number of patients examined was not sufficient to definitively exclude this hypothesis.
Although immunoblotting and mass spectrometry indicate that neuronal clathrin light chain is absent from our synaptic vesicle preparation (Figure 1), we could not definitively exclude that our synaptic vesicle fraction actually contained a small number of endocytic vesicles, which had merely lost their coats during purification [28].
Although our review findings lead us to suggest that beta-blockers do not reduce AAA growth rate, the use of surrogate markers and the small number of RCTs assessing the efficacy of beta-blockers do not definitively exclude the possibility of benefit from beta-blockers.
This fits with the observation that COL2A1 lies within a cluster of genes on human chromosome 12q13.11 syntenic with mouse chromosome 15 band F2 that are known to be maternally imprinted [23], although again we cannot definitively exclude autosomal random mono-allelic expression.
However, we cannot definitively exclude a clinically meaningful difference.
In this case it was difficult to definitively exclude a predisposing immunocompromising condition.
