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In our dataset, 187 gained introns do not appear to have been definitively created by any of the proposed mechanisms of intron gain.
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To definitively test this, we created a mutant form of UNC-116 in which three point mutations were introduced in the C-terminal MT-binding motif.
This is definitively not about creating the architectural equivalent of the hair shirt, but about making the best possible contexts for the things that matter in life, on paring back the accretions of surface and behaviour to what is essential: the glory lies not in the act of removal, but in the experience of what is left.
And we know definitively when that menu was created, because the club magazine did an article about the menu in 1916". Fogarty's one known visit to the DAC took place the next winter, so although he might have liked the drink and taken the recipe back to New York, he probably didn't come up with it.
Think of the way that Apple created iTunes to definitively separate the iPod from all the other MP3 players.
The vaccine was created before scientists had definitively determined the nature of this year's predominant flu strain and thus doesn't match up perfectly.
Here's an uncontroversial gauntlet to throw down: Ocarina of Time is definitively the greatest video game ever created.
In one case it claimed definitively that Labor's spending commitments had created "a cumulative deficit, or black hole, over and above what is currently in the budget of $67bn.
The report, signed by the office's director, Robert A. Clouse, found the mound to be "definitively cultural" in origin, as opposed to having been created by a natural process like erosion.
Few rock instrumentalists get treated so reverently, and fewer still created their own aura and era so definitively for all time.
Under Diane's leadership, VMware created the market for mainstream virtualization and VMware definitively leads what is now a virtualization software industry.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com