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While this class of fracture was recognized prior to the introduction of the anti-resorptive bisphosphonate drugs and recently likened to stress fractures, the mechanism(s) that lead to atypical fractures have not been definitively identified.
In our group, 3 of 8 HCCs which were not definitively diagnosed by reading CEUS scan due to atypical perfusion pattern or obvious attenuation of liver were considered as HCC after review of US post-CEUS scan.
Advances have been made regarding management of some of these processes; it is established that the atypical intraductal epithelial proliferations are more frequently definitively upgraded with the use of wider gauge devices (for example, 11 G, 8 G) to ductal carcinoma in situ.
Because of atypical imaging findings, the tumors could not be definitively diagnosed.
Because of atypical imaging findings, these tumors could not be definitively diagnosed.
In this study, in cases where atypical cells were present but could not be definitively identified as cancer cells, the peritoneal cytology was considered to be negative.
The other two cases were composed of distinct areas that definitively met the criteria for BNCT and for chordoma, as well as atypical areas that did not meet the criteria for either chordoma or BNCT.
To date no imaging modality can definitively diagnose PCNSL, and early tumor biopsy is still recommended when PCNSL is suspected especially with atypical radiological findings [ 31].
Thus, for tumors with atypical features that do not suggest SPN, EUS-FNA is a useful and safe method of definitively diagnosing SPN preoperatively.
Not definitively.
JM: Atypical.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com