Sentence examples for definitive surrogate from inspiring English sources

As a definitive surrogate marker for disease progression has not been established, this trial combined state-of-the-art comprehensive testing of various outcomes considered relevant to the study of neuroprotection.

In fact, protocol dictates that after in vivo biology has been demonstrated and efficacy inferred by improvements in surrogate measures, definitive studies should seek evidence of benefit using end points that measure important, patient-centered outcomes, including intermediate and longer term survival [ 21].

Not definitive, just definite.

Because of the difficulty in establishing reliable surrogacy, debates still remain around the use of surrogate endpoints as definitive efficacy criteria [ 25, 26].

Such endpoints would be used as surrogates for the definitive endpoint.

Although controversy remains over the potential use of proteinuria as a surrogate end point in definitive Phase III clinical trials, proteinuria is an ideal marker for use as an intermediate outcome in earlier phase trials.

Thus incidence and money spent on cancer services are indicative rather than definitive but are used as a surrogate indicator of comparable incidence of cancer and proportional expenditure on cancers services but nothing on Australia, Canada, Japan and the USA.

Although both statistical and mechanistic elements suggested that AAA expansion rate is a valid surrogate marker of AAA rupture, definitive inference is only likely when using the true clinical endpoint (i.e. AAA rupture).

This estimation may not be around the primary endpoint for the definitive study but could be on a surrogate or an early assessment of an endpoint which may be assessed at a later time point in the definitive study [ 3].

To obtain surrogacy status definitive evidence is required, demonstrating that the surrogate end point is causally related to the clinical end point.

For each side in the seven-year struggle over Guantánamo, this is the definitive moment in an argument that is a surrogate for other arguments about America's definition of justice and its role in the world.