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Neutrophils pre-incubated with each inhibitor demonstrated significant reductions in NET release following OO extract stimulation (p ≤ 0.01, Fig. 3A), confirming a definitive role for each of these enzymes in OO extract-induced NET release.
The roles of LPA receptors in lung fibrosis, asthma, and acute lung injury have been investigated using genetically engineered LPA receptor deficient mice and there appears to be a definitive role for endogenous LPA and its receptors in the pathogenesis of pulmonary inflammatory diseases.
Many consider this to have been a "definitive role" for Whitaker.
However, a definitive role for oxidative damage in aging has not yet been established [6], [8].
In contrast, T-cell deficient mice succumbed to pulmonary infection with C. neoformans strain H99γ, supporting a definitive role for T cells in mediating protection against acute infection.
Our study provided the direct evidence for a definitive role for EPS in coordinating S motility in cellular groups, which is another important biological function of EPS in M. xanthus.
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However, definitive roles for all these components remain to be established [ 44– 44].
Large prospectively designed and well powered clinical trials will help to specify definitive roles for these new diagnostic tools in daily clinical practice.
As more studies are conducted in this area, possibly looking at the expression of these markers in metastatic specimens, more definitive roles for the behavior of radixin and moesin in prostate cancer may be discovered, possibly expanding on existing models regarding cell growth and proliferation, and the involvement of members of the Protein 4.1B superfamily in these processes.
However, long-term oncologic outcomes are essential to determine the definitive role of laparoscopic surgery for rectal cancer.
Our finding of absence of significant association of hemoglobin glycation with vitamin D further questions its definitive role in T2DM except for poor lifestyle in our overall population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com