Though as the New York City FC deal shows, the stadium being in place, once considered a non-negotiable cornerstone of any credible bid, is perhaps not such a definitive requirement as it once was.
Moreover, a definitive requirement of Alzheimer's disease, instead of dementia more broadly, helps ensure that studies remain comparable.
We present arguments to support the proposition that randomisation will enable greater clarity in the interpretation of the phase II trial results, as well as allowing for more precise estimates of the effect size and sample size requirements for definitive phase III trials.
The study was, importantly, a prospective double-blind, randomized trial, thus clearly conforming to the design requirements for definitive clinical trials.
Accumulation of amyloid-β (Aβ) fibrils in the form of amyloid plaques is a neuropathological requirement for definitive diagnosis [1].
These results provide a definitive example of the requirement of axons in endothelial guidance leading to the parallel patterning of nerves and vessels in vivo.
Although in this study RT-CGM was not used, these pilot data provide the rationale, robust power calculation and proven study design for a definitive RCT, without the requirement for an education alone arm.
The currently well-established genotyping methods (e.g. LSP and SNP typing), as used in this study, should be a requirement for definitive differentiation of species from the M. tuberculosis complex.
While the use of REBOA would not reduce the requirement for definitive haemostasis (and indeed might increase it, if more patients are alive to receive it), it is postulated that it could deliver a more haemodynamically stable patient to the proceduralist, and perhaps therefore reduce the total blood transfusion requirements.
Not definitive, just definite.
There are no definitive answers regarding sample size requirements for IRT, however sample sizes of 100 are often adequate [ 61].
