Besides the essentiality of frozen section, extended resections were required in some cases in order for a definitive margin-negative surgery because of the aggressive nature of the disease [ 23].
Huston et al. compared the number of systematically shaved cavity edges to the achieved definitive histopathological margin status and found an inverted correlation between the rate of positive margin status and the total volume of breast tissue removed.
Lesions in the hand, especially those arising from metacarpals require resection with adequate margins and definitive structural reconstructions to ensure preservation of hand architecture, function and cosmesis.
For skin margins without definitive presentation, mapping biopsies were performed in outpatient clinic to determine the extent of resection.
In cases of close or positive margins and definitive treatment, superficial radiofrequency hyperthermia was offered as an additional modality, leading to concurrent application in 29 patients (69%).
Not definitive, just definite.
Until this work provides definitive results, demonstration of adequate margins of exposure relative to levels of biological activity (not all of which is necessarily adverse) could provide assurances of safety (Thomas et al. 2013).
It may have a role as a complementary treatment in patients with close or intralesional margins or as definitive therapy in unresectable patients, even if a local control at 5 years can be obtained in much less than 50% of patients [ 6, 22, 23].
This isn't definitive proof of anything -- the margin of error on the calculation is fairly high, depending on which assumptions one makes.
Better delineations of the lesion border and margin result in a more definitive interpretation.
