Sentence examples similar to definitive limitation from inspiring English sources

Although recent studies found polyurethane-cuffed tracheal tubes to be associated with significantly reduced VAP rate, major limitations of these studies preclude definitive conclusions; these limitations include the use of subglottic aspiration [ 3], before/after study design [ 4], and clinical criteria to define pneumonia [ 4, 5].

However, due to the great variability between studies in terms of the intervention protocols and outcome measures, as well as methodological limitations, definitive recommendations as to optimal treatment protocols and the potential of such an intervention as a safe and effective home-based treatment cannot be made at this point.

Although the present results could not be considered as definitive due to the limitations mentioned, they could provide useful information for clinicians and decision makers.

Given the methodological limitations identified, definitive randomised trials are needed to re-appraise this research question.

These limitations prevented definitive conclusions to be drawn about the effect of FCM on serum phosphate in CKD patients.

Although the RCT evidence may suggest a reduction in post-CPB inflammation by statin therapy, the evidence is not definitive due to significant limitations.

12 Pollak and Wachter (1975) present a definitive analysis of the limitations of the Becker model when the assumption of homogeneous separability is relaxed and when joint production is considered.

The authors stated that the VCS deficit may "represent a long-lasting, adverse alteration in neurobehavioral function" caused by chronic, environmental perc exposures, although they cautioned that methodologic limitations preclude definitive attribution of causation.

However, here too, and in the extended ORIGIN analysis (9), there were limitations for definitive interpretation as: (i) there is a rapid drop-off after the median 6.2 year follow-up (arguably too short to evaluate the full effect of exposure on cancer risk); (ii) there was interrupted glargine exposure in the intervention arm and (iii) there was considerable contamination across the arms (10, 11).

Not definitive, just definite.

However, the relatively small number of patients analysed in our series represents a clear limitation for a definitive conclusion about the role of EGFR promoter methylation in determining response to anti-EGFR treatments, and our findings should be considered speculative.