Finally, the data and themes were reviewed and refined, until associations and explanations could be drawn from the definitive concepts.
The current classification replaces the morphologic and arbitrary dichotomy of epithelial and non-epithelial neoplasms with the histogenetically definitive concepts of ectodermal/endodermal and non-ectodermal/endodermal neoplasms.
In this way, Blumer distinguishes between definitive concepts that precisely define the object of enquiry, and sensitizing concept, which give 'a general sense of reference and guidance in approaching empirical instances' [ 34] (page 7).
Philosophers of biology recognize that the genes of classical genetics, molecular genetics, evolutionary genetics, and more recently developmental genetics do not necessarily map onto each other.[13] Difficulties arriving at a definitive gene concept arise even when we confine ourselves to contemporary molecular biology.
No definitive therapeutical concept has evolved so far.
Dubbed Select Bus Service, or SBS, the MTA's version forgoes just about everything that would appear to be definitive of the concept, such as dedicated stations and lanes, and simply asks its passengers to buy their (paper) tickets at machines distinct from those that vend the more common MetroCards.
Moreover, the argument may be continued, since some of these singular terms those of the form 'the number of Fs' figure in the identity condition definitive of the concept of number (Hume's Principle, see below), the objects referred to are properly called "numbers".
Herein, we provide definitive proof of concept for this approach and report the first PAD inhibitor, ruthenium red (Ki of 17 μM), to preferentially bind the apoenzyme.
Our study provides definitive proof-of-concept into the mechanism by which DENV evades immune recognition and activation in vivo.
Despite the limitation in the number of animals per group, our study provides definitive proof-of-concept data for how the innate response against DENV infection influence the molecular basis of the DENV host interaction, from PRRs to the adaptive immune response, in an animal model, as well as insights into the mechanism by which DENV evades immune recognition and activation in vivo.
