This was largely due to the lack of defined transcription start/stop sites and uneven transcript coverage, which made definitive classification challenging.
However, the phenotype variation makes definitive identification challenging, and further characterization of the observed fine protrusions in δ-opioid receptor-OE keratinocytes is required.
The first and definitive attempt to challenge Rossini's work, Otello is the only Shakespeare opera that generates the same critical response as the original, including G.B. Shaw's quip that "instead of Otello being an Italian opera written in the style of Shakespeare, Othello is a play written by Shakespeare in the style of Italian opera".
Let's explore a bit: I have sometimes perhaps been too eager to challenge definitive statements related to human-driven global warming for fear they will provide ammunition to those working to foment doubt and maintain stasis on our energy menu.
We also show that active learning brings definitive advantages in challenging databases when accompanied with powerful feature representations.
A dearth of appropriately designed trials makes development of definitive treatment paradigms challenging.
The aforementioned high-intensity, intermittent, skill-based nature of the sport partly challenges definitive classifications of fatigue in tennis.
An extended follow-up of a large cohort in which AGD is measured in infancy would be definitive, but logistically challenging.
Given the current fascination with extreme sports, it was probably inevitable that this storied place -- a spot of Buddhist myth" regarded by some as the model for James Hilton's Shangri-La -- would be recast as "the definitive white-water exploratory challenge".
First, it provides a definitive reference for the challenge, including full descriptions of the task design, data capture and baseline systems along with a description and evaluation of the 26 systems that were submitted.
The criteria were taken from the definitive paper on aspirin challenge 10 and were as follows: Increased symptoms [see Fig. 1 recorded by VAS, plus either 25% or greater decrease in the nasal airway (represented by a reduction of cross-sectional area: Amin or volume 0 12 cm)] as assessed by acoustic rhinometry or a 40% decrease in nasal inspiratory peak flow.
