Exact(11)
While they potentially improve diarrhea caused by infections or antibiotics and may ease symptoms of irritable bowel syndrome, so far the evidence of any definitive benefit is limited.
However, the definitive benefit of such interventions should be further investigated.
Cancer vaccines — Treatments that aim to harness the immune system have yet to show a definitive benefit.
Some animal studies of green tea extracts suggest that they may prevent several types of tumors, but no definitive benefit has yet emerged in studies involving humans.
To date, definitive benefit is only demonstrated for aminoglycosides [ 20, 21].
As yet, these trials have not shown a definitive benefit for surgical removal, including the recent STICH2 trial [ 140].
Similar(49)
Despite major technical advancements in BIM, it has not been fully adopted and its definitive benefits have not been fully capitalized upon by industry stakeholders.
Prospectively identifying sensitive or excluding resistant patient populations to achieve definitive clinical benefit led to successful development of several targeted therapies.
Although the planned sample size was not achieved, the results of this study suggested that adjuvant oral fluoropyrimidine monotherapy can provide a definitive survival benefit in advanced gastric cancer patients, with minimal adverse effects.
According to our opinion, we have not proven a definitive clinical benefit of evaluating s-inhibin B in the follow-up of TC survivors, where infertility might be a concern.
More recently, a meta-analysis considered 12 RCTs that included a total of 1,237 patients [ 10] and came to conclusions that were more definitive: no benefit was seen on mortality but there was improved oxygenation at 24 hours (13% improvement in PaO2/FiO2 ratio) at the cost of increased risk of renal dysfunction (relative risk 1.50, 95% confidence interval 1.11 to 2.02).
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