Although an infectious etiology has been postulated, a definitive causative agent has not been identified.
In reciprocal transplants, the target environmental gradient, say temperature, often covaries with other features of the environment, often rendering inferences on the definitive selective agent inconclusive.
Lawrence Wright's definitive piece, "The Agent," which ran in The New Yorker in 2006, helps answer that question.
He is author of Within Arms Length: A Secret Service Agent's Definitive Inside Account of Protecting the President.
Only in one case — a straight New York to Manila round-trip request — did the Web score a definitive victory over an agent at a Filipino storefront in Woodside, Queens, and then only by about $50.
The particular combinations employed may vary between institutions and geographical regions and, although a number of studies have compared cisplatin- with carboplatin-based regimens, no definitive evidence suggests either agent to be better.
Arguably, we lack what we seek most in a diabetes treatment: definitive demonstration that an agent can safely lower A1C in a sustained and durable manner by definitively modifying disease progression, does so with minimal side effects (e.g., hypoglycemia), favorably improves CVD risk factors (e.g., weight, lipids, and blood pressure), and reduces cardiovascular and other morbidity and mortality.
The definitive identification of infectious agents implicated in other autoimmune rheumatic diseases requires further investigations.
Golimumab safety was consistent with other anti-TNF agents, although definitive conclusions regarding long-term safety require further monitoring.
The results of these trials will help define the role of targeted agents after definitive treatment of early-stage and locally advanced NSCLC.
