IHD cases were identified in the five-year period from April 1 , 1993to March 31 , 1998using a definition validated by Lix et al. [24].
This definition of a diabetes case is consistent with the definition validated in prior research [ 9].
Ninety-five percent of patients interviewed met the Council of State and Territorial Epidemiologists clinical case definition, validating the Arizona laboratory-based case definition for surveillance in a coccidiodomycosis-endemic area.
RIFLE is the first widely accepted AKI definition, validated in over half a million patients worldwide [ 5- 7]; however, the urine criteria are frequently discarded [ 8- 16].
A case of S. aureus SSTI was defined as infection in a patient who had 1) a principal discharge diagnosis of SSTI (according to an epidemiologic case definition validated in a previous study [ 11 ]), 2) an additional discharge diagnosis of B956, and 3) no additional discharge diagnoses containing either A410 or J152.
Since there is no definition validated, we considered the situation as RA flare when at least one of the following conditions occurred: an increase in SDAI, an increase in ESR and/or CRP not due to a concomitant infection, an increase in DAS score to moderate or high disease activity, and a lower class in EULAR response as compared to previous reevaluation.
We expect the genetic element definitions validated here can be collectively expanded to create collections of public-domain standard biological parts that support reliable forward engineering of gene expression at genome scales.
To benchmark the unsteady cases, a normalized displacement velocity was defined to differentiate flame propagation from autoignition, and this definition was validated against the steady cases.
Herein, we highlight the importance of predictive biomarkers in the scenario of modern oncology, underlying the major challenges in biomarker definition and validating procedures needed before clinical translation.
The most efficient approach could be to choose a clinical case definition, and validate it with a sample of cases that are confirmed by laboratory tests.
