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This emphasises that the timeframe used in the definition of the first trimester may differ for medicines depending on prescribing characteristics.
This difference could be attributed to that study including bone and joint infections, and using a definition of healthcare associated infection with a substantially shorter timeframe for previous hospitalization compared with ours (30 days versus 180 days) and that did not include previous antibiotic treatment, a criterion met by 47.6% of our patients.
In light of the seriousness of the condition and the urge to treat as early as possible to prevent refractory SE, the timeframe has been progressively shortened to a pragmatic definition of 5 min ongoing seizures [ 2].
Coinciding with the timeframe of this study, there was debate on the definition of refractory CM (due to the introduction of onabotulinumtoxinA as a preventive treatment), resulting in a proposal from the European Headache Federation Expert Group to modify the definition to also include patients who had contraindications to or no effect from onabotulinumtoxinA treatment.
Prevalence studies that adopt this definition of a case (ie, an individual who reports at least one headache episode during that time) necessarily use a timeframe of 1 year and usually report the findings as 1-year prevalence.
No definition of "substantial".
Definition of crimes.
Definition of perfect casting.
Definition of patriarch.
His definition of charity?
Definition of entrepreneur.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com