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The specific parameters used in the definition of the patterns were in part dictated by the size of the analysed genomes in order to obtain sufficient data sample for statistical evaluations.
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The definition of the Design Patterns Ontology Model was done through the analysis of the Design Patterns attributes as contextual elements that characterize and define the Design Patterns.
In addition, an improvement of the single cell sequencing technology will allow better characterization of the progression of tumor and definition of the pattern of mutations in more aggressive subclonal cells.
However, there is no universal agreement on the definition of these patterns, resulting in heterogeneity of the prevalence of asynchrony and of the association between asynchrony and outcome.
The present study was aimed at a clear definition of the NVC patterns and fine phenotyping in well-defined SSc clinical subtypes in association with serum VEGF-A levels.
The design of the model is following the Design Patterns description template as it is given by (Gamma et al. 1995) for the definition of the GoF Design Patterns.
In the absence of a true definition of this pattern in the literature, we identify them as 'proliferative papillary cystic changes with spindle cells and remodeling'.
However, because of the differences in study design, in populations studied and in the definition of histological patterns, the comparison between the validity of the biomarkers has to be carried out cautiously.
Although the definition of the muting pattern in (8) is similar to the definition of the muting decision in (4), the two concepts are different.
It includes, besides the basic one, measurements of blood flow volumes in carotid and vertebral arteries and in jugular and vertebral veins (inflow and outflow), with the definition of the drainage pattern.
The broader definition of the VO/OV pattern is employed in order to show the generalization of positional variation constrained by Mandarin information structure.
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