Although the optimal definition of VAP is controversial [ 41], the lack of standardized definition and the difficulty of blinding render the results susceptible to ascertainment bias.
Owing to the ±1 residue extension in loop length definition allowed because of the difficulty in defining the termini of the secondary structures and to the wide definition around regions in "l/g" and in "b/p" conformations, loops can cluster into more than one group.
The last two sections provide a player and Game Design oriented definition of the challenge and difficulty notions in games.
The difficulty of definition probably increases the difficulty of recognition.
Using this definition, the difficulty of employing inconsistent definitions of a default event among the 123 included banks can be avoided.
Despite the presence of multiple definitions and the difficulty of using them in different populations, the general pathophysiological processes are similar across age and ethnicity.
Because of the lack of standardized definitions and the difficulty in assessing reversibility of AKI, the concept of prerenal failure has been recently challenged [ 39].
However, there are numerous difficulties involved in the development of group education such as for example the inadequate or imprecise definition of the educational objectives, the difficulties in evaluating the process and the results as well as the variable attendance of the patients and the limitations in the material and human resources available.
The main outcome measures were the data completeness of information at the patient and variable levels, the discrepancy for data variable definitions, and the difficulty of data collection.
The definition of residents in difficulty used by the postgraduate medical training authorities in our region was outlined in an official document entitled "Handling Problematic Residencies".
In this case, primarily the resolution of haplogroups K1a1 and K1a12 by full mtGenomes and the subsequent definition of the mitochondrial phylogeny caused difficulties in haplogrouping of this sample, which can be attributed to the relatively high mutability (and hence weak diagnostic value) of sites 11,914 and 5460 defining haplogroups K1a1 and K1a12, respectively.
