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However, in Senegal, the rate of malarial attack was higher among children co-infected with S. mansoni [45] and an association between A. lumbricoides infection and severe malaria was found elsewhere, despite of the loose definition of severity in this particular case [46].
Similar to other working classification systems, strengths and limitations have been identified including the adequacy of the specimen, the definition of severity between grades, the reproducibility, the adequacy of the specimens, the types of rejection, and the integration of newer technologies such as molecular and genomic approaches.
Of note, our definition of severity vs. mild is clearly described in the Methods section, and represents a consensus between physicians from Poland, Sweden, and France, as reached during our FP6 CE project (NEUPROCF).
For other domains, the definition of severity was shown in Table 1.
First, they were not used to establish the definition of severity.
In patients with severe osteoporosis, risk reduction for clinical osteoporotic fractures was 24%9595% CI: 6 – 39%) using the WHO definition of severity and 26%9595% CI: 5 – 33%) using the FRAX definition of severity.
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However, these studies had several limitations, including retrospective design [ 17], and inconsistent definitions of severity ranging from severe pancreatitis based on the Atlanta criteria to mortality [ 17, 18].
In a parallel analysis, the impact of the restriction to patients with severe osteoporosis was also studied using two definitions of severity: the WHO criteria (a T-score of −2.5 or less and a prior fragility fracture) and the probability-based assessment of fracture risk (FRAX®).
It may be that at this stage of illness caregivers agree more with patients self ratings, or that the higher validity we found may be a feature of POS, which uses more detailed definitions of severity and effect on the person, than the terms mild, moderate, severe, used in many scales.
Reporting practices and use of ER versus clinics and definitions of severity can differ among countries.
The problem of defining clinically-relevant operational definitions of sleep variables was part of the motivation for the development by the American Academy of Sleep Medicine of new scoring criteria in 2007 [54], although it is unclear whether the new definitions of severity are better predictors of symptoms.
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