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The remission rates one year after surgery were lower than in the Italian study — 42 percent and 37 percent — at least in part because the American study used a stricter definition of remission.
The promising results on the predictivity of MRD evaluation at the end of induction treatment has raised the need of a new definition of remission.
A more stringent definition of remission was also considered (a YMRS score of <8); remission rates were low (<25%) with this definition regardless of treatment, demonstrating the difficulty in reducing symptoms to this level over such a short time period.
Using a MADRS score of less than 10 as a definition of remission [32], we then dichotomized the depressed cohort into those currently remitted, and those who were not.
Establishing a standarized definition of remission is a controversial issue.
Stricter criteria were applied for the definition of remission.
Criteria for inclusion included published RCTs with a clear definition of remission using established outcome measures.
For example, no consensus on the definition of remission has yet been reached.
A growing body of research has linked this definition of remission to several different improved outcomes.
Each definition of remission requires the absence of pharmacologic treatment during the defined observation period.
There is no international consensus on the definition of remission for Cushing's disease after transsphenoidal surgery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com