Sentence examples for definition of dose from inspiring English sources
We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models.
We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects.
Nanotoxicity assessment requires a definition of dose and standardized modes of exposure in nanomaterial uptake and cytotoxicity studies to determine the hazard that is posed by naturally occurring and engineered (E- NM.
The main problem with prescription of drugs to children is: choice of drug and definition of dose.
As a result of discussions regarding cardiac toxicity seen in some early patients, the definition of dose limiting cardiac toxicity was revised during the study.
Using the same definition of dose escalation as we applied here, Gilbert et al. investigated dose increases among patients first treated with infliximab or etanercept [ 17].
However, it requires careful optimization, both for the design of the appropriate pretargeting reagents, bispecific immunoconjugates binding tumour antigens and the small molecule selected to carry the activity, and for the definition of dosing and administration schedules.
The focus of current research on lead toxicity in industrial populations is in the definition of dose-response relationships, particularly at low levels of exposure.
Dosimetric data obtained by XRF will permit accurate definition of dose-response relationships for such chronic consequences of lead exposure as central and peripheral neurologic impairment, renal disease.
The statistical calculation was made on toxicity issues and was based on the definition of dose-limiting toxicity (DLT) used in our previous phase-I trial (Hofheinz et al, 2005).
Overall, this first-in-human dose study provides a detailed approach on how to integrate the evaluation of safety (including concentration-associated QTc assessments as part of the definition of dose-limiting toxicity), pharmacokinetics and pharmacodynamics of a multikinase inhibitor in AML patients.
