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The absence of a clear null hypothesis may make the definition of comparator groups in a TES difficult (mean (SD) 7.4 (1.74)) and should therefore be stated where appropriate (see table 3 for details on method of data analysis).
For each included study, the study design, quality using the Oxford scale, number of included patients, definition of comparator groups, duration of use and mean dose of MTX, duration of follow-up as well as the results expressed in incidence rates, risk (relative risk (RR) or odds ratio), incidence rate (IR) or standardised mortality rate have been described.
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Additional file 1: Provides additional details on definition of intervention and comparator.
It is reported to facilitate the definition of population groups, interventions, comparators, and outcomes of interest.
The output of comparator is the desired PWM signal.
In contrast, the perturbation score we applied in the present study is independent of comparator data.
The search was not limited to one kind of comparator.
However, differences in patient populations, comparators, and selection and/or definition of secondary endpoints make it difficult to draw direct cross-trial comparisons.
No definition of "substantial".
Definition of crimes.
Definition of perfect casting.
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