As most test combinations were only evaluated by one study and the definition of a positive test varied for the tests investigated by more than one study, it was not possible to draw conclusions regarding the diagnostic accuracy of these test combinations.
The introduction of an approximation level for fitness evaluation of generated test data and the definition of an efficient test strategy for processing test goals, increases the performance of evolutionary testing considerably.
As Simpson's index of diversity is very much dependent on the collection of isolates tested, a more strict definition of such a test panel might be required for evaluation of subtyping methods.
The control condition consisted of a PDF file of one page which gave general information about self-testing (definition of a self-test and the types of self-tests that are available).
One of these offered no definition of a positive test [ 45], whereas the other defined a positive test as "<75 degrees" [ 33].
The combination of negative leukocyte and nitrite test had a NPV of 88% (CI: 84%92%%), however the results show interpretation is further influenced by the definition of a negative test because the PPV is only 51% if a positive test is defined as >0.
Furthermore, publications often lacked information on dietary restrictions, the definition of a positive test result (cut-off value, number of positive samples), and number of test failures.
Depending on the population studied, the assay used and the definition of a positive test result, up to 25 30% of patients with DTC have a positive test for TgAbs at the time of diagnosis (40, 41).
Based on the definition of a positive test (C.
