The case definition was constructed to maximize sensitivity, acknowledging that a proportion of cases meeting the EIP standardized definition may have had other conditions known to mimic encephalitis.
Toovey and colleagues' definition was constructed post hoc based on a selected group of adverse events taken from the psychiatric, neurological, and injury body systems in the reports.
The scenario definition was constructed on the basis of preliminary planning discussions with key PRRINN-MNCH staff, including the National Programme Manager, the Deputy National Programme Manager and the Yobe State Team Manager.
These three major definitions are constructed as the convolution of derivative of a given differentiable function and power law, exponential decay law or Mittag-Leffler law [1 5].
Using treatment guidelines current in 1998 [6], [7], standard definitions were constructed for which patients were eligible for recommended care (e.g., PCP prophylaxis for patients with a CD4 count <200 cells/μL).
The 2003 definitions were constructed to detect more cases of sepsis than the 1992 definitions.
The revised 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions were constructed to detect more cases of SIRS/sepsis.
Different definitions were constructed, based on three sources of information, i.e. self-report, clinical diagnosis and radiography.
Hypertension and diabetes definitions were constructed to be similar across studies, combining self-report, measured blood pressure or blood glucose and medication use.
Furthermore, medical demarcations, inclusion criteria and definitions are constructed by the current level of biomedical knowledge and consensus which also influence the differential diagnosis.
