For specificity, we define a positive class as a domain of concentrations of Toxin A and Toxin B, which cause less than 50% population mortality after a specified test duration; all other combinations of concentrations by definition are assigned to the negative class.
The study comprised 6 study groups: 21 patients with active TB and 11 patients with a positive IGRA result, who had a history of TB exposure, but no symptoms of active disease, and therefore by definition being assigned to the group of LTBI.
Gene symbols and definitions were assigned to the accession number using Ensembl annotations downloaded via EnsMart [ 69].
Aristotle explains that the word chosen by the opponent can have several meanings, provided one definition can be assigned to each and each definition is assigned a different word.
For each N+ definition, participants were assigned to one of four biomarker groups; A−N−, A+N−, A−N+, or A+N+.
For each N+ definition, participants were assigned to an A/N biomarker group with A−N− denoting normal amyloid PET and normal neurodegeneration, A+N− denoting abnormal amyloid PET but no neurodegeneration, A−N+ denoting normal amyloid PET but abnormal neurodegeneration, and A+N+ denoting abnormal amyloid PET and abnormal neurodegeneration.
According to the US National Institutes of Health (NIH), specific definitions have been assigned to the terms "biomarker," "clinical endpoint," and "surrogate endpoint".
A laboratory-based study conducted in Phnom Penh, Cambodia, found an MDR TB prevalence of 5.5% in 98 samples from HIV-infected patients, but case definitions were not assigned to the drug resistance patterns (7).
After abstracting data on each manuscript we assigned the definition(s) of absenteeism employed by authors into initial groups based on similarities allowing, where necessary, reported definition(s) to be assigned to more than one group.
Despite the differences in implementation across methods (e.g., how SNPs are assigned to genes, definition of gene boundaries, gene set annotation used, pathway enrichment determination) there are common themes to the results.
