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The JUVENTAS (reJUVenating ENdothelial progenitor cells via Transcutaneous intra-Arterial Supplementation) trial is the first randomized, placebo-controlled, double-blinded clinical trial on repeated intra-arterial BM mononuclear cell (MNC) infusion in 110 to 160 CLI patients, designed to provide definite proof for the efficacy of stem cell therapy.
Thus, also a limitation of the present study is that we did not determine the effect of sEH inhibition in animals lacking LOX activity and therefore we cannot provide definite proof for an involvement of LOX in the progression of renal failure after sEH inhibitor treatment.
This study provides definite proof for the absence of the putative 'red' chlorophyll trimer in Synechocystis and narrowed the number of coupled pigment dimers to two.
Definite proof for a reduced chemosensitivity of advanced dMMR tumours can only be obtained from prospective randomised studies with chemotherapy vs observation.
Although the high affinity is consistent with the formation of a Cys2His2 complex, definite proof for such coordination should come from X-ray structure determination and/or EXAFS.
Definite proof for prospective prediction mechanisms can only be found in studies that are able to uncover the purely endogenous neural activity associated with the generation of predictions.
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Since we do not have definite proof of cost-effectiveness of either of the approaches, the policy for invitation will be up to the practices themselves.
While clients of MF Global say that it was unprecedented for the firm to abandon a longstanding business practice to wire money to customers who were closing accounts, the documents are not definite proof of wrongdoing.
In the absence of definite proof of dorsal root ganglia involvement or other gold standard, we provisionally classified the SNN patients in the study population according to two levels of certitude for the diagnosis of SNN.
Definite proof of safety and efficacy will unfortunately have to await results from clinical trials with ONYX-015.
The first and principal dilemma in clinically suspected VPGI is to obtain definite proof of the graft infection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com