Definite heart failure is defined as a combination of the presence of typical symptoms or signs of heart failure, such as breathlessness at rest or during exertion, ankle edema, and pulmonary crepitations, confirmed by objective evidence of cardiac dysfunction (chest X-ray, echocardiography).
While it is not definite proof, failure to observe a strong and frequent nuclear localization of the overexpressed Xenopus FLAG-GnRH-R strengthens the conclusion that FLAG-hGnRH-RI is not localized to the nuclear membrane due to its overexpression.
Also, for definite heart failure, the diagnosis has to have been made by a medical specialist, preferably a cardiologist or an internist.
It is difficult to conclude which approach is best, because neither study showed a definite link between failure and BMD value, and our study had a median time from the DXA scan to failure of 86 days (IQR: 4 280).
This is in line with the recommendation that root canal treatment (with uncertain outcome) should be reviewed for 4 years before a definite decision of failure (to heal) is made [ 1].
Our definition of "definite" volume loss is a conservative one, as growth failure may exist at this age range without actual loss of volume.
In all, that report strongly accords with our observation that a dose reduction below 18 Gy involves a small but definite risk of treatment failure.
Not definitive, just definite.
The single impact data scatter necessitated to conduct repeated impact tests at reduced number of locations to search for a definite answer for the possible failure process in the vicinity of the clamped edges of the plate.
And in the face of adversity, I reminded myself that failure is never definite and success is not final.
